Manuel Villalón

Fono oficina: (56-2) 354-2873

Fono laboratorio: (56-2) 354-2870
Fax: (56-2) 354-1850
Ubicación oficina: Edificio Decanato 5º piso

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Profesor Titular

Unidad de Endocrinología y Reproducción

Departamento de Fisiología,

Facultad de Ciencias Biológicas,

Pontificia Universidad Católica de Chile

Alameda 340, Santiago, Chile

Estudios

Profesor en Ciencias Naturales y Biología, Pontificia Universidad Católica de Chile, (1978)

M,Sc.. Engineering, University of Washington, (1986)

Ph.D..Bioengineering, University of Washington, USA. (1989)

Postdoctorado Cystic Fibrosis Foundation, University of Washington, USA.

Especialización: Fisiología Celular y Transporte Mucociliar

Cursos

Pregrado

BIO166C

Ingeniería de la Célula: Estructura y Función

1 - A non-genomic signaling pathway shut down by mating changes the estradiol-induced gene expression profile in the rat oviduct
Autor(es): Parada-Bustamante A, Orihuela PA, Rios M, Cuevas CA, Orostica ML, Velasquez LA, Villalon MJ & Croxatto HB
Año: 2010. 139(3):631-44.
Reproduction
2 - Enchacement of visual perception with use of dynamic cues
Autor(es): Andia ME, Plett J, Tejos C, Guarini MW, Navarro ME, Razmiliz D, Meneses L, Villalon MJ & Irarrazabal P
Año: 2009. 250(2):551-7.
Radiology
3 - Characterization and phenotypic variation with passage number of cultured human endometrial adenocarcinoma cells
Autor(es): Kato S, Espinoza N, Lange S, Villalon M, Cuello M & Owen GI
Año: 2008. 40(2):95-102.
Tissue Cell
4 - Effect of oestradiol and progesterone on the instant and directional velocity of microsphere movements in the rat oviduct: gap junctions mediate the kinetic effect of oestradiol
Autor(es): Rios M, Hermoso M, Sanchez TM, Croxatto HB & Villalon MJ
Año: 2007. 19(5):634-40.
Reproduction, Fertility and development
5 - The oestrogen metabolite 2-methoxyoestradiol alone or in combination with tumour necrosis factor-related apoptosis-inducing ligand mediates apoptosis in cancerous but not healthy cells of the human endometrium
Autor(es): Kato S, Sadarangani A, Lange S, Villalon M, Brañes J, Brosens JJ, Owen GI & Cuello M
Año: 2007. 14: 351-368.
Endocrine-Related Cancer
6 - Catechol-o-methyltransferase and methoxyestradiols participate in the intraoviductal nongenomic pathway through which estradiol accelerates egg transport in cycling rats
Autor(es): Parada-Bustamante A, Orihuela PA, Rios M, Navarrete-Gomez PA, Cuevas CA, Velasquez LA, Villalon MJ & Croxatto HB
Año: 2007. 77(6):934-41.
Biology of Reproduction
7 - ATP and adenosine trigger the interaction of plasma membrane IP3 receptors with protein kinase A in oviductal ciliated cells
Autor(es): Barrera N, Morales B & Villalon M
Año: 2007. 364(4):815-21.
Biochemical and Biophysical Research Communications
8 - TRAIL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract
Autor(es): Sadarangani A, Kato S, Espinoza N, Lange S, Llados C, Espinosa M, Villalon M, Lipkowitz S, Cuello M & Owen GI
Año: 2007. 12(1):73-85.
Apoptosis
9 - Class of skew-distributions: theory and applications in biology
Autor(es): Barrera N, Galea M, Torres S & Villalon M
Año: 2006
Statistics
10 - 17-beta-Estradiol upregulates COX-2 in the rat oviduct
Autor(es): Martinez SP, Hermoso M, Farina M, Ribeiro ML, Rapanelli M, Espinosa M, Villalon M & Franchi A
Año: 2006. 803-4:155-64
Prostaglandins & Other Lipid Mediators

11 - Human-like rodent amyloid-?-peptide determines Alzheimer pathology in aged wild-type Octodon degu
Autor(es): Inestrosa NC, Reyes AE, Chacon MA, Cerpa W, Villalon A, Montiel J, Merabachvili G, Aldunate R, Bozinovic F & Aboitiz F
Año: 2005
Neurobiology of Aging
12 - TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity
Autor(es): Andrade YN, Fernandez J, Vasquez E, Fernandez-Fernandez JM, Arniges M, Sanchez TM, Villalon M & Valverde MA
Año: 2005
Journal of Cellular Biology
13 - Social cues and hormone levels in male Octodon degus (Rodentia): a field test of the challenge hypothesis
Autor(es): Soto-Gamboa M, Villalon M & Bozinovic F
Año: 2005
Hormones and Behavior
14 - Progesterone pre-treatment potentiates EGF pathway signaling in the breast cancer cell line ZR-75
Autor(es): Carvajal A, Espinoza N, Kato S, Pinto M, Sadarangani A, Monso C, Aranda E, Villalon M, Richer JK, Horwitz KB, Brosens JJ & Owen GI
Año: 2005
Breast Cancer Research and Treatment
15 - Regulation of the immunoexpression of aquaporin 9 by ovarian hormones in the rat oviductal epithelium
Autor(es): Branes MC, Morales B, Rios M & Villalon MJ
Año: 2005
American Journal of Physiology & Cell Physiology
16 - demonstrates that P2X2 receptors are trimers, but that P2X6 receptor subunits do not oligomerize
Autor(es): Barrera NP, Morales B, Torres S & Villalon M
Año: 2005
Journal of Biological Chemistry
17 - Principles: mechanisms and modeling of synergism in cellular responses
Autor(es): Barrera NP, Morales B, Torres S & Villalon M
Año: 2005. 26(10):526-32.
Trends in Pharmacology Science
18 - Tissue factor is regulated by epidermal growth factor in normal and malignant human endometrial epithelial cells
Autor(es): Kato S, Pinto M, Carvajal A, Espinoza N, Monso C, Bravo L, Villalon M, Cuello M, Quest AF, Suenaga A, Brosens JJ & Owen GI
Año: 2005
Thrombosis & Haemostasis
19 - Effect of in vivo administration of epidermal growth factor on prostaglandin production and NOS activity in term rat placentae. Possible participation of placental EGF receptors
Autor(es): Ribeiro ML, Fariña M, Billi S, Perez Martinez S, Branes MC, Villalon M & Franchi A
Año: 2005
Placenta
20 - Epidermal growth factor prevents prepartum luteolysis in the rat
Autor(es): Ribeiro ML, Aisemberg J, Billi S, Fariña MG, Meiss R, McCann S, Rettori V, Villalon M & Franchi AM
Año: 2005
PNAS - Proceedings of the National Academy of Sciences of the United States of America

21 - Prediction of synergism on frequency of responses in the attojoule range
Autor(es): Barrera N, Torres S, Morales B & Villalon M
Año: 2004
Physical Chemistry Chemical Physics
22 - Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1
Autor(es): Kato S, Pinto M, Carvajal A, Espinoza N, Monso C, Sadarangani A, Villalon M, Brosens JJ, White JO, Richer JK, Horwitz KB & Owen GI
Año: 2004
Journal of Clinical Endocrinology & Metabolism
23 - Plasma and intracellular membrane inositol 1,4,5-trisphosphate receptors mediate the Ca(2+) increase associated with the ATP-induced increase in ciliary beat frequency
Autor(es): Barrera NP, Morales B & Villalon M
Año: 2004
American Journal of Physiology & Cell Physiology
24 - Plasma and intracellular membrane inositol 1,4,5-trisphosphate receptors mediate the Ca(2+) increase associated with the ATP-induced increase in ciliary beat frequency
Autor(es): Barrera NP, Morales B & Villalon M
Año: 2004
American Journal of Physiology. Cell Physiology
25 - Acidic pH and increasing [Ca2+] reduce the swelling of mucins in primary cultures of human cervical cells
Autor(es): Espinosa M, Noe G, Troncoso C, Ho SB & Villalon M
Año: 2002
Human Reproduction
26 - Platelet activating factor increases ciliary activity in hamster oviduct through epithelial production of prostaglandin E2
Autor(es): Hermoso M, Barrera NP, Morales B, Perez S & Villalon M
Año: 2001
Pflugers Archive: European journal of Physiology
27 - Effect of sexual hormones upon the different type of mucins expressed in cultures of human cervix
Autor(es): Espinosa M, Noe G, Ho SB & Villalon M
Año: 2000
Biology of Reproduction
28 - Effect of nitric oxide synthase inhibitors on ovum transport and oviductal smooth muscle activity in the rat oviduct
Autor(es): Perez Martinez S, Viggiano M, Franchi AM, Herrero MB, Ortiz ME, Gimeno MF & Villalon M
Año: 2000
Journal of Reproduction and Fertility
29 - Functional cross-talk after activation of P2 and P1 receptors in oviductal ciliated cells
Autor(es): Morales B, Barrera NP, Uribe P, Mora C & Villalon M
Año: 2000
American Journal of Physiology. Cell Physiology
30 - Sperm interaction with human oviductal cells in vitro
Autor(es): Morales P, Palma V, Salgado AM & Villalon M
Año: 1996
Human Reproduction

Manuel Villalón

Manuel Villalón

Fono oficina: (56-2) 354-2873

Fono laboratorio: (56-2) 354-2870 Fax: (56-2) 354-1850 Ubicación oficina: Edificio Decanato 5º piso

Profesor Titular

Unidad de Endocrinología y Reproducción

Estudios

Cursos

Líneas de Investigación:

STUDY OF A NOVEL HUMAN FOLLICLE STIMULATING HORMONE (FSH) VARIANT: ELUCIDATION OF THE PHYSIOLOGICAL ROLE AND PATHOLOGICAL IMPLICATIONS

PROCESOS INFLAMATORIOS ASOCIADOS A LA RESPUESTA ALERGICA PRODUCEN ALTERACIONES EN LAS VIAS DE SEÑALIZACION INTERCELULAR Y COORDINACION DEL TRANSPORTE MUCOCILIAR EN EL EPITELIO NASAL HUMANO

ELUCIDATION OF THE REGULATION AND PATHOPHYSIOLOGICAL ACTIONS OF TISSUE FACTOR IN BREAST AND ENDOMETRIAL CANCER.

1 - A non-genomic signaling pathway shut down by mating changes the estradiol-induced gene expression profile in the rat oviduct

2 - Enchacement of visual perception with use of dynamic cues

3 - Characterization and phenotypic variation with passage number of cultured human endometrial adenocarcinoma cells

4 - Effect of oestradiol and progesterone on the instant and directional velocity of microsphere movements in the rat oviduct: gap junctions mediate the kinetic effect of oestradiol

5 - The oestrogen metabolite 2-methoxyoestradiol alone or in combination with tumour necrosis factor-related apoptosis-inducing ligand mediates apoptosis in cancerous but not healthy cells of the human endometrium

6 - Catechol-o-methyltransferase and methoxyestradiols participate in the intraoviductal nongenomic pathway through which estradiol accelerates egg transport in cycling rats

7 - ATP and adenosine trigger the interaction of plasma membrane IP3 receptors with protein kinase A in oviductal ciliated cells

8 - TRAIL mediates apoptosis in cancerous but not normal primary cultured cells of the human reproductive tract

9 - Class of skew-distributions: theory and applications in biology

10 - 17-beta-Estradiol upregulates COX-2 in the rat oviduct

11 - Human-like rodent amyloid-?-peptide determines Alzheimer pathology in aged wild-type Octodon degu

12 - TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity

13 - Social cues and hormone levels in male Octodon degus (Rodentia): a field test of the challenge hypothesis

14 - Progesterone pre-treatment potentiates EGF pathway signaling in the breast cancer cell line ZR-75

15 - Regulation of the immunoexpression of aquaporin 9 by ovarian hormones in the rat oviductal epithelium

16 - demonstrates that P2X2 receptors are trimers, but that P2X6 receptor subunits do not oligomerize

17 - Principles: mechanisms and modeling of synergism in cellular responses

18 - Tissue factor is regulated by epidermal growth factor in normal and malignant human endometrial epithelial cells

19 - Effect of in vivo administration of epidermal growth factor on prostaglandin production and NOS activity in term rat placentae. Possible participation of placental EGF receptors

20 - Epidermal growth factor prevents prepartum luteolysis in the rat

21 - Prediction of synergism on frequency of responses in the attojoule range

22 - Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1

23 - Plasma and intracellular membrane inositol 1,4,5-trisphosphate receptors mediate the Ca(2+) increase associated with the ATP-induced increase in ciliary beat frequency

24 - Plasma and intracellular membrane inositol 1,4,5-trisphosphate receptors mediate the Ca(2+) increase associated with the ATP-induced increase in ciliary beat frequency

25 - Acidic pH and increasing [Ca2+] reduce the swelling of mucins in primary cultures of human cervical cells

26 - Platelet activating factor increases ciliary activity in hamster oviduct through epithelial production of prostaglandin E2

27 - Effect of sexual hormones upon the different type of mucins expressed in cultures of human cervix

28 - Effect of nitric oxide synthase inhibitors on ovum transport and oviductal smooth muscle activity in the rat oviduct

29 - Functional cross-talk after activation of P2 and P1 receptors in oviductal ciliated cells

30 - Sperm interaction with human oviductal cells in vitro

31 - Characterization of a marker for tracheal basal cells

32 - Characterization of a marker of differentation for tracheal cells independent of ciliation

33 - Control of ciliary movement in mammalian oviductal ciliated cells

34 - The transport of cumulus masses through the ampullae of the oviducts in the pig-tailed, Macaca nemestrina

35 - Enrichment of subpopulations of respiratory epithelial cells using flow cytometry

36 - Recondensation of mast cell secretory products in vitro

37 - Autoregulation of beat frequency in respiratory ciliated cells: Demonstration by viscous load

38 - Development of an in vitro model of primate cervical goblet cells

39 - Stimulus-response coupling in mammalian ciliated cells: demonstration of two mechanisms of control for cytosolic [Ca++]

40 - Kinetic measurement of bacterial adherence to eukaryotic cells

41 - The oviductal cilia and Kartagener's Syndrome

42 - Molecular mechanism of mucin secretion : I. Role of intragranular charge shielding

43 - Molecular mechanism of product storage and release in mucin secretion. II. The role of extracellular Ca++

44 - The role of calmoduline in the regulation of ciliary movement in mammalian epitheliary cilia

45 - Ovum transport and fertility following postovulatory treatment with estradiol in rats

46 - Hormonal regulation of ciliary function in the oviduct: The effect of beta-adrenergic agonists

47 - Differential transport of fertilized and unfertilized ova in the rat

48 - Changes in the nutritional state of a lacting women during full nursing

Fono laboratorio: (56-2) 354-2870
Fax: (56-2) 354-1850
Ubicación oficina: Edificio Decanato 5º piso