Federico Leighton

Fono oficina: (56-2) 354-2836
Ubicación oficina: Portugal 49, Edificio Decanato 2do piso

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Profesor Titular Adjunto

Centro de Nutrición Molecular y Enfermedades Crónicas

Departamento de Fisiología,

Facultad de Ciencias Biológicas,

Pontificia Universidad Católica de Chile

Alameda 340, Santiago, Chile

Estudios

Licenciado en Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile (1962)

Médico Cirujano, Facultad de Medicina, Universidad de Chile (1962)

Postgrado en Estados Unidos y Bélgica (1965 – 1977)

Cursos: Biología Molecular de la Célula, Patología Molecular, Nutrición Salud y Antioxidantes

1 - Modelling, implementation and application of a flexible manufacturing cell
Autor(es): Leighton F, Osorio R & Lefranc G
Año: 2011
International Journal of Computers Communications & Control
2 - Mediterranean diet and red wine protect against oxidative damage in young volunteers
Autor(es): Urquiaga I, Strobel P, Perez D, Martinez C, Cuevas A, Castillo O, Marshall G, Rozowski J & Leighton F
Año: 2010
Atherosclerosis
3 - Diagnostic test results and pathology associated with the 2007 canadian H7N3 highly pathogenic avian influenza outbreak
Autor(es): Pasick J, Berhane Y, Hisanaga T, Kehler H, Hooper-McGrevy K, Handel K, Neufeld J, Argue C & Leighton F

Año: 2010
Avian Diseases
4 - Survey of influenza a viruses circulating in wild birds in Canada 2005 to 2007
Autor(es): Pasick J, Berhane Y, Kehler H, Hisanaga T, Handel K, Robinson J, Ojkic D, Kibenge F, Fortin M, King R, Hamel A, Spiro D, Parmley J, Soos C, Jenkins E, Breault A, Caswell D, Davies C, Rodrigue J, McAloney K & Leighton F

Año: 2010
Avian Diseases
5 - Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
Autor(es): Minniti AN, Cataldo R, Trigo C, Vasquez L, Mujica P, Leighton F, Inestrosa N & Aldunate R
Año: 2009
Aging Cell
6 - Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays
Autor(es): Quiroga T, Goycoolea M, Matus V, Zuñiga P, Martínez C, Garrido M, Aranda E, Panes O, Pereira J & Mezzano D
Año: 2009
British Journal of Haematology
7 - Health impact of Mediterranean diets in food at work
Autor(es): Polic G, Strobel P, Perez D, Martinez C, Vasquez L, Castillo O, Villarroel L, Echeverria G, Urquiaga I, Mezzano D & Rozowski J
Año: 2009
Public Health & Nutrition
8 - Mediterranean food and diets, global resource for the control of metabolic syndrome and chronic diseases
Autor(es): Urquiaga I, Echeverria G, Polic G, Castillo O, Liberona Y, Rozowski J, Perez D, Martinez C, Vasquez L, Strobel P, Mezzano D & Leighton F

Año: 2008. 98:150-73
World Review of Nutrition and Dietetics
9 - Lipoperoxidation and protein oxidative damage exhibit different kinetics during septi shock
Autor(es): Andresen HM, Regueira HT, Bruhn A, Perez D, Strobel P, Dougnac A, Marshall G & Leighton F
Año: 2008
Mediators Inflamm
10 - Changes in cardiovascular risk factors associated with wine consumption in intervention studies in humans
Autor(es): Leighton F and Urquiaga I
Año: 2007
Annals of Epidemiology

11 - Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products
Autor(es): San Martin A, Foncea R, Laurindo FR, Ebensperger R, Griendling KK & Leighton F
Año: 2007
Free Radical Biology and Medicine
12 - Oxidative stress in critically ill patients
Autor(es): Andresen HM, Regueira HT & Leighton F
Año: 2006
Revista Médica de Chile
13 - A central role of eNOS in the protective effect of wine against metabolic syndrome
Autor(es): Leighton F, Miranda-Rottman S & Urquiaga I
Año: 2006
Cell Biochemistry and Function
14 - Red wine reduces oxidative stress in patients with acute coronary syndrome
Autor(es): Guarda E, Godoy I, Foncea R, Perez D, Romero C, Venegas R & Leighton F
Año: 2005
International Journal of Cardiology
15 - Antioxidant and Pro-oxidant effects of red wine and its fractions on Cu(II) induced LDL oxidation evaluated by absorbance and chemiluminescence measurements
Autor(es): Hötzer KA, Henriquez C, Pino E, Miranda-Rottmann S, Aspillaga A, Leighton F & Lissi E
Año: 2005
Free Radical Research
16 - Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes
Autor(es): Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R & Leighton F
Año: 2005
Biochemical Journal
17 - The effect of red wine on endotelial function and oxidative stress in patients with acute coronary syndrome
Autor(es): Guarda E, Godoy I, Marchant E, Fajuri A, Martinez A, Foncea R, Perez D, Romero C, Venegas R & Leighton F
Año: 2005
International Journal of Cardiology
18 - The effect of red wine on endotelial function and oxidative stress in patients with acute coronary syndrome
Autor(es): Guarda E, Godoy I, Marchant E, Fajuri A, Martínez A, Foncea R, Pérez D, Romero C, Venegas R & Leighton F

Año: 2005 104(1): 35-38
International Journal of Cardiology
19 - Wine and Health: Evidence and Mechanisms
Autor(es): Urquiaga I and Leighton F

Año: 2005. 95: 133-150
Heart Metabolism
20 - Cytoprotection by neutral fraction of tanat red wine against oxidative stress-induced cell death
Autor(es): Echeverry C, Blasina F, Arredondo F, Ferreira M, Abin-Carriquiry J, Vasquez L, Aspillaga A, Diez M, Leighton F & Dajas F
Año: 2004
Journal of Agricultural and Food Chemistry

21 - Effect of mediterranean and occidental diets, and red wine, on plasma fatty acids in humans. An intervention study
Autor(es): Urquiaga I, Guasch V, Marshall G, San Martin A, Castillo O, Rozowski J & Leighton F
Año: 2004
Biological Research
22 - Haemostatic cardiovascular risk factors: differential effects of red wine and diet on healthy young population
Autor(es): Mezzano D and Leighton F
Año: 2004
Pathophysiology of Haemostasis and Thrombosis
23 - Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis
Autor(es): Mezzano D, Leighton F, Strobel P, Martinez C, Marshall G, Cuevas A, Castillo O, Panes O, Muñoz B, Rozowski J & Pereira J
Año: 2003
Journal of Clinical Nutrition
24 - Modifying oxidative stress by nutritional intervention
Autor(es): Urquiaga I and Leighton F

Año: 2003. 19: 23-29
Heart Metabolism
25 - Determinacion del indice de resistencia insulinica mediante homa en una poblacion de la region Metropolitana de Chile
Autor(es): Acosta AM, Escalona M, Maiz A , Pollak F & Leighton F
Año: 2002
Revista Médica de Chile
26 - Ingesta de nutrientes en adultos mayores de la comuna de Providencia, Santiago, Chile
Autor(es): Castillo O, Rozowski J, Cuevas A, Maiz A, Soto M & Leighton F
Año: 2002
Revista Médica de Chile
27 - Cytochemical and biochemical demonstration of an ATPase in membranes of human peroxisomes
Autor(es): Koenig C, Skorin C, Araya C, Toro A, Valencia C, Leighton F & Santos MJ
Año: 2002
Journal of Histochemistry and Cytochemistry
28 - Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice
Autor(es): Mardones P, Strobel P, Miranda S, Leighton F, Quiñones V, Amigo L, Rozowski J, Krieger M & Rigotti A
Año: 2002
Journal of Nutrology
29 - Juice and phenolic fractions of the berry Aristotelia chilensis inhibit LDL oxidation in vitro and protect human endothelial cells against oxidative stress
Autor(es): Perez D, Strobel P, Foncea R, Diez M, Vasquez L, Urquiaga I, Castillo O, Cuevas A, San Martin A & Leighton F
Año: 2002
Journal of Agricultural and Food Chemistry
30 - Wine, diet, antioxidant defenses and oxidative damage
Autor(es): Koenig C, Araya C, Skorin C, Valencia C, Toro A, Leighton F & Santos M
Año: 2002
Annals of the New York Academy of Sciences

31 - Zinc Catechin complexes in aprotic medium. Redox chemistry and interaction with superoxide radical anion
Autor(es): Bodini M, Del Valle MA, Tapia R, Leighton F & Berrios P
Año: 2001
Polyhedron
32 - Study of the iron catechin complexes in dimethyl sulphoxide. Redox chemistry and interaction with superoxide radical anion in this medium
Autor(es): Bodini M, Del Valle MA, Tapia R, Leighton F & Gonzalez L
Año: 2001
Boletín de la Sociedad Chilena de Química
33 - Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors
Autor(es): Mezzano D, Leighton F, Martinez C, Marshall G, Cuevas A, Castillo O, Panes O, Muñoz B, Perez DD, Mizon C, Rozowski J, San Martin A & Pereira J
Año: 2001
European Journal of Clinical Nutrition
34 - Inflammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia
Autor(es): Mezzano D, Pais EO, Aranda E, Panes O, Downey P, Ortiz M, Tagle R, Gonzalez F, Quiroga T, Caceres S, Leighton F & Pereira J
Año: 2001
Kidney International
35 - Spontaneous urinary chemiluminescence and diet. An intervention study in humans
Autor(es): Pizarro M, Lissi EA, Marshall G, Martin AS & Leighton F
Año: 2001
Luminescence
36 - Diferencias en antioxidantes plasmaticos segun nivel socioeconomico en mujeres chilenas
Autor(es): Rozowski J, Cuevas A, Castillo O, Marin PP, Strobel P, Perez DD, San Martin A, Barriga C, Maiz C & Leighton F
Año: 2001
Revista Médica de Chile
37 - NO-mediated OxyHB oxidation is inhibited in vitro by polyphenolic compounds using S-nitroso-homocysteine as a NO donor
Autor(es): Carvajal C, Foncea R & Leighton F
Año: 2000
Journal of Physiology
38 - Endothelial cell oxidative stress and signal transduction
Autor(es): Foncea R, Carvajal C, Almarza C & Leighton F
Año: 2000
Biological Research
39 - The role of oxidative stress in the toxicity induced by amyloid-B peptide in Alzheimer's disease
Autor(es): Miranda S, Opazo C, Larrondo LF, Muñoz FJ, Ruiz F, Leighton F & Inestrosa NC
Año: 2000. 62:633-648.
Progress in Neurobiology
40 - Cardiovascular risk factors in vegetarians: normalization of hyperhomocysteinemia with vitamin B12 and reduction of platelet aggregation with n-3 fatty acids
Autor(es): Mezzano D, Kosiel K, Martinez C, Cuevas A, Panes O, Aranda E, Strobel P, Perez D, Pereira J, Rozowski J & Leighton F
Año: 2000
Thrombosis Research

41 - A comparison of methods employed to evaluate antioxidant capabilities
Autor(es): Perez D, Leighton F, Aspee A, Aliaga C & Lissi E
Año: 2000
Biological Research
42 - Plant polyphenol antioxidants and oxidative stress
Autor(es): Urquiaga I and Leighton F
Año: 2000
Biological Research
43 - A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers
Autor(es): Cuevas AM, Guasch V, Castillo O, Iribarra V, Mizon C, San Martin A, Strobel P, Perez D, Germain AM & Leighton F

Año: 2000. 35: 143-148
Lipids
44 - Iron complexes of Quercetinin aprotic medium. Redox chemistry and interaction with superoxide anion radical
Autor(es): Bodini ME, Copia G, Tapia R, Leighton F & Herrera L
Año: 1999
Polyhedron
45 - Plasma polyphenols and antioxidants, oxidative DNA damage, and endothelial function, in a diet and wine intervention study in humans
Autor(es): Leighton F, Cuevas A, Guasch V, Perez DD, Strobel P, San Martin A, Urzua U, Diez MS, Foncea R, Castillo O, Mizon C, Espinoza MA, Urquiaga I, Rozowski J, Maiz A & Germain A
Año: 1999
Drugs under experimental and clinical research
46 - Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells
Autor(es): Miranda S, Foncea R, Guerrero J & Leighton F
Año: 1999
Biochemical and Biophysical Research Communications
47 - Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine
Autor(es): Mezzano D, Muñoz X, Martinez C, Cuevas A, Panes O, Aranda E, Guasch V, Strobel P, Muñoz B, Rodriguez S, Pereira J & Leighton F
Año: 1999
Thrombosis & Haemostasis
48 - Estudios epidemiologicos y posibles mecanismos de los efectos protectores
Autor(es): Leighton F, Castro C, Barriga C & Urquiaga I
Año: 1997
Revista Médica de Chile
49 - Indicadores de riesgo de ateroesclerosis. Evaluacion mediante coronariografia en hombres no diabéticos con colesterol igual o menor a 240 mg/dl
Autor(es): Arteaga A, Martinez A, Follak F, Borghesi L, Catalan L, Acosta AM & Leighton F
Año: 1995
Revista Médica de Chile
50 - Dislipidemicos con cardiopatia coronaria. Efecto de diferentes dosis de acidos grasos omega 3 (w3) sobre los lipidos y lipoproteinas sericas
Autor(es): Arteaga A, Villanueva CL, Skorin C, Guasch V, Solis de Ovando F, Velasco N, Acosta AM & Leighton F
Año: 1993
Revista Médica de Chile

51 - Flavonoids as stabilizers of fish oil: an alternative to synthetic antioxidants
Autor(es): Nieto S, Garrido A, Sanhueza J, Loyola LA, Morales G, Leighton F & Valenzuela A
Año: 1993
Journal of American Oil Chemistry Society
52 - Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyl transferase I in isolated rat hepatocytes
Autor(es): Skorin C, Necochea C, Johow V, Soto U, Grau AM, Bremer J & Leighton F
Año: 1992
Biochemical Journal
53 - Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation
Autor(es): Leighton F, Bergseth S, Rortveit T, Christiansen EN & Bremer J
Año: 1989
Journal of Biological Chemistry
54 - Detection of an ATPase activity in rat liver peroxisomes
Autor(es): del Valle R, Soto U, Necochea C & Leighton F
Año: 1988
Biochemical and Biophysical Research Communications
55 - El Dr. Luis Vargas Fernandez, premio nacional de ciencias 1985
Autor(es): Skorin C, Soto U, Necochea C & Leighton F
Año: 1986
Revista Médica de Chile
56 - Protein phosphorylation in peroxisomes
Autor(es): Leighton F
Año: 1986
Biochemical and Biophysical Research Communications
57 - Large cation-selective pores from rat liver peroxisomal membranes incorporated to planar lipid bilayers
Autor(es): Labarca P, Wolff D, Soto U, Necochea C & Leighton F
Año: 1986
Journal of Membrane Biology
58 - Peroxisomal organization in normal and cerebrohepatorenal (Zellweger) syndrome fibroblasts
Autor(es): Santos MJ, Ojeda JM, Garrido J & Leighton F
Año: 1985
PNAS - Proceedings of the National Academy of Sciences of the United States of America
59 - Characterization of peroxisomes in Chinese hamster ovary cells in culture.
Autor(es): Santos MJ, Garrido J, Oliver C, Robbins AR & Leighton F
Año: 1985
Experimental Cell Research
60 - Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes
Autor(es): Leighton F, Persico R & Necochea C
Año: 1984
Biochemical and Biophysical Research Communications

Federico Leighton

Federico Leighton

Fono oficina: (56-2) 354-2836 Ubicación oficina: Portugal 49, Edificio Decanato 2do piso

Profesor Titular Adjunto

1 - Modelling, implementation and application of a flexible manufacturing cell

2 - Mediterranean diet and red wine protect against oxidative damage in young volunteers

3 - Diagnostic test results and pathology associated with the 2007 canadian H7N3 highly pathogenic avian influenza outbreak

4 - Survey of influenza a viruses circulating in wild birds in Canada 2005 to 2007

5 - Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans

6 - Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays

7 - Health impact of Mediterranean diets in food at work

8 - Mediterranean food and diets, global resource for the control of metabolic syndrome and chronic diseases

9 - Lipoperoxidation and protein oxidative damage exhibit different kinetics during septi shock

10 - Changes in cardiovascular risk factors associated with wine consumption in intervention studies in humans

11 - Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products

12 - Oxidative stress in critically ill patients

13 - A central role of eNOS in the protective effect of wine against metabolic syndrome

14 - Red wine reduces oxidative stress in patients with acute coronary syndrome

15 - Antioxidant and Pro-oxidant effects of red wine and its fractions on Cu(II) induced LDL oxidation evaluated by absorbance and chemiluminescence measurements

16 - Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes

17 - The effect of red wine on endotelial function and oxidative stress in patients with acute coronary syndrome

18 - The effect of red wine on endotelial function and oxidative stress in patients with acute coronary syndrome

19 - Wine and Health: Evidence and Mechanisms

20 - Cytoprotection by neutral fraction of tanat red wine against oxidative stress-induced cell death

21 - Effect of mediterranean and occidental diets, and red wine, on plasma fatty acids in humans. An intervention study

22 - Haemostatic cardiovascular risk factors: differential effects of red wine and diet on healthy young population

23 - Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis

24 - Modifying oxidative stress by nutritional intervention

25 - Determinacion del indice de resistencia insulinica mediante homa en una poblacion de la region Metropolitana de Chile

26 - Ingesta de nutrientes en adultos mayores de la comuna de Providencia, Santiago, Chile

27 - Cytochemical and biochemical demonstration of an ATPase in membranes of human peroxisomes

28 - Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice

29 - Juice and phenolic fractions of the berry Aristotelia chilensis inhibit LDL oxidation in vitro and protect human endothelial cells against oxidative stress

30 - Wine, diet, antioxidant defenses and oxidative damage

31 - Zinc Catechin complexes in aprotic medium. Redox chemistry and interaction with superoxide radical anion

32 - Study of the iron catechin complexes in dimethyl sulphoxide. Redox chemistry and interaction with superoxide radical anion in this medium

33 - Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors

34 - Inflammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia

35 - Spontaneous urinary chemiluminescence and diet. An intervention study in humans

36 - Diferencias en antioxidantes plasmaticos segun nivel socioeconomico en mujeres chilenas

37 - NO-mediated OxyHB oxidation is inhibited in vitro by polyphenolic compounds using S-nitroso-homocysteine as a NO donor

38 - Endothelial cell oxidative stress and signal transduction

39 - The role of oxidative stress in the toxicity induced by amyloid-B peptide in Alzheimer's disease

40 - Cardiovascular risk factors in vegetarians: normalization of hyperhomocysteinemia with vitamin B12 and reduction of platelet aggregation with n-3 fatty acids

41 - A comparison of methods employed to evaluate antioxidant capabilities

42 - Plant polyphenol antioxidants and oxidative stress

43 - A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers

44 - Iron complexes of Quercetinin aprotic medium. Redox chemistry and interaction with superoxide anion radical

45 - Plasma polyphenols and antioxidants, oxidative DNA damage, and endothelial function, in a diet and wine intervention study in humans

46 - Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells

47 - Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine

48 - Estudios epidemiologicos y posibles mecanismos de los efectos protectores

49 - Indicadores de riesgo de ateroesclerosis. Evaluacion mediante coronariografia en hombres no diabéticos con colesterol igual o menor a 240 mg/dl

50 - Dislipidemicos con cardiopatia coronaria. Efecto de diferentes dosis de acidos grasos omega 3 (w3) sobre los lipidos y lipoproteinas sericas

51 - Flavonoids as stabilizers of fish oil: an alternative to synthetic antioxidants

52 - Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyl transferase I in isolated rat hepatocytes

53 - Free acetate production by rat hepatocytes during peroxisomal fatty acid and dicarboxylic acid oxidation

54 - Detection of an ATPase activity in rat liver peroxisomes

55 - El Dr. Luis Vargas Fernandez, premio nacional de ciencias 1985

56 - Protein phosphorylation in peroxisomes

57 - Large cation-selective pores from rat liver peroxisomal membranes incorporated to planar lipid bilayers

58 - Peroxisomal organization in normal and cerebrohepatorenal (Zellweger) syndrome fibroblasts

59 - Characterization of peroxisomes in Chinese hamster ovary cells in culture.

60 - Peroxisomal fatty acid oxidation is selectively inhibited by phenothiazines in isolated hepatocytes

61 - Acyl-CoA synthetase and the peroxisomal enzymes of ß-oxidation in human liver

62 - Carnitine acyl transferase and acyl-coenzyme A hydrolase activities in human liver

63 - Conducta etica en la investigacion biomedica I

64 - Conducta etica en la investigacion biomedica II. Aspectos eticos de la relacion entre ciencias biomedicas y sociedad

65 - Subcellular fractionation studies on the organization of fatty acid oxidation by liver peroxisomes

66 - Isolation of peroxisomes by isopycnic density centrifugation in metrizamide gradients and analysis of the distribution of constituents with multiple localization by constrained linear regression

67 - Function of peroxisomes in animal cells

68 - Introduccion practica del estudiante de medicina a la investigacion biomedica

69 - Purification of the peroxisomal fatty acyl-CoA oxidase from rat liver

70 - Fatty acid oxidation by human liver peroxisomes

71 - Detection of peroxisomal fatty-acyl CoA oxidase activity

72 - Properties of fatty acyl-CoA oxidase from rat liver, a peroxisomal flavoprotein.

73 - Cytoplasmic gradient analysis of liver nuclei organization

74 - Structure, enzymatic composition and turnover of proliferated peroxisomes. A study of the trophic effects of Su-13437 on rat liver

75 - Effect of pyrazole on rat liver catalase

76 - Isolation of lysosomes

Fono oficina: (56-2) 354-2836
Ubicación oficina: Portugal 49, Edificio Decanato 2do piso